Endocrine Abstracts

Case Report:A 69 year old man was referred for assessment of hypoglycaemic events. Type 2 diabetes was diagnosed 4 years previously and treatment with metformin 2000mg per day had provided adequate control (HbA1c 7.5%). In the 4 months prior to referral, the patient had lost 8kg in weight and had had more than 10 episodes of sweating, tremor and disorientation. Eventually capillary blood glucose measurements were undertaken which suggested hypoglycaemia which was confirmed...

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by parathyroid, anterior pituitary and pancreatic islet tumours. Primary hyperparathyroidism is the first clinical manifestation in >85% of patients, although in some patients pancreatic and pituitary tumours may precede the occurrence of primary hyperparathyroidism. The earliest occurrence of MEN1-tumours has been reported at the age of 5 years following which the age-related penetr...